In the bloody aftermath of their showdown with Ashcroft, CSI Lilith Adams and her team are struggling to hold it together. When Orchid tracks them down, she brings information on terrifying new threats and offers her help-an offer they have no choice but to accept.

As mercenaries move in on all sides, the group races to protect those closest to them while attempting to unravel Luminita's mysterious plans regarding the Wormwood virus. The noose is tightening, and they're running out of time. Will they find a solution before Aaron and Luminita destroy everything, or will trust ultimately lead to their downfall?