It has been four years since ancient languages expert, Cloe LeJeune, her son, J.E., and the Monsignor nearly lost their lives while defeating the Karics forces at Masada. Cloe has never lost her passion for translating old texts, and one evening while attempting to decipher digitalized scraps culled from a jar left to her by the Sicari, Cloe quickly realizes that something terrible is about to happen. As she prepares to race to the Vatican to tell the Pope of her discovery, a giant man delivers cryptic cards to seven unsuspecting strangers who suddenly find themselves heading toward New Orleans, Louisiana, with no reason why.

As violence and disease rock the world, the Vatican is abruptly destroyed, the Pope is forced into hiding, and the United States is driven to implement marshal law across the land. While one man emerges from the shadows to subtly pit people against each other, Cloe and her cohorts must find and assemble the mysterious seven in order to stop his evil mission. As the pale horse of Revelation is loosed upon Earth, a fierce battle between good and evil ensues leaving Cloe betrayed by someone close to her and the future of humanity resting in the hands of seven innocent souls.